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Polyomavirus nephropathy (PVN) is a common viral infection of renal allografts, with biopsy-proven incidence of approximately 5%. A generally accepted morphologic classification of definitive PVN
Although sporadic cases of PVAN had been described as early as 1978 ( 12 ), the appreciation of BK virus (BKV) as a serious threat to kidney transplantation became evident in the late 1990s when several centers reported a rise in PVAN cases ( 13–18 ). In some renal transplant patients, the necessary use of immunosuppressive drugs has the side-effect of allowing the virus to replicate within the graft, a disease called BK nephropathy. From 1–10% of renal transplant patients progress to BK virus associated nephropathy (BKVAN) and up to 80% of these patients lose their grafts. The classification is broken into three classes, Banff Class 1-3.
In nonrenal solid organ or stem cell transplant recipients, BK virus infection complicates the clinical course of recipients by causing hemorrhagic cystitis in 5% to 15% and polyomavirus nephropathy in fewer patients, ranging from mild to severe, with renal failure requiring renal replacement therapy.7 BK virus disease is associated with the total cumulative immunosuppression to Sar A, Worawichawong S, Benediktsson H, Zhang J, Yilmaz S, Trpkov K. Interobserver agreement for Polyomavirus nephropathy grading in renal allografts using the working proposal from the 10th Banff Conference on Allograft Pathology. Hum Pathol. 2011;42:2018-2024. KEYWORDS: polyomavirus, BK virus, BK nephropathy, kidney transplant BACKGROUND Awareness of the importance of BK polyomavirus is emerging among the kidney transplant community.
ClinicalTrials.gov lists trials that are related to Polyomavirus allograft nephropathy. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies. Please note: Studies listed on the ClinicalTrials.gov website are listed for informational purposes only; being listed does not reflect an endorsement by GARD or the NIH.
In the past, the term chronic allograft nephropathy (CAN) was used to Polyomavirus nephropathy: a current perspective and clinical. Kidney Disease – Mineral and Bone Disease,. CKD-MBD), vars Polyomavirus- associated nephropathy in renal transplantation: interdis- ciplinary analyses Prospective study of polyomavirus type BK replication and nephropathy in Adjuvant low-dose cidofovir therapy for BK polyoma-virus interstitial nephritis in such as children, the elderly, HIV, Hepatitis C positive patents, highly sensitized patients, and patients who develop post-transplant polyomavirus nephropathy.
, BK polyomavirus viremia occured in 13% and BK polyomavirus nephropathy in 8% of kidney transplant recipients, but the frequencies of viremia (8–62%) and BK polyomavirus nephropathy (5–10%) vary considerably in published literature .
Click on the link to go to ClinicalTrials.gov to read descriptions of these studies. Please note: Studies listed on the ClinicalTrials.gov website are listed for informational purposes only; being listed does not reflect an endorsement by GARD or the NIH. 2020-09-17 · Polyomavirus BK (BKV) nephropathy, an emerging cause of renal-allograft failure, may be linked to immunosuppressive regimens containing tacrolimus or mycophenolate mofetil.
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with Polyoma Virus Nephritis. Poster presented at the American Transplant Congress meeting in April 2003 at Washington, D.C.. 10.
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Poster presented at the American Transplant Congress meeting in April 2003 at Washington, D.C.. 10.
The principle of balancing the immune system remains the mainstay of therapeutic strategy. Polyomavirus-associated nephropathy (PVAN) is an emerging cause of kidney transplant failure affecting 1–10% of patients. As uncertainty exists regarding risk factors, diagnosis, and intervention, an independent panel of experts reviewed the currently available evidence and prepared this report. Polyomavirus-associated nephropathy (PVAN) is one of the most common viral complications in renal transplant recipients and is an increasingly recognized cause of renal transplant dysfunction and graft loss.
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In some renal transplant patients, the necessary use of immunosuppressive drugs has the side-effect of allowing the virus to replicate within the graft, a disease called BK nephropathy. From 1–10% of renal transplant patients progress to BK virus associated nephropathy (BKVAN) and up to 80% of these patients lose their grafts.
The aim av BM Eriksson — Management of polyomavirus- associated nephropathy in renal transplant recipients.